Wan et al. also reported that non-responsive children with infantile epileptic spasm syndrome had upregulated Clostridioides and Peptoclostridium_phage_p630P2 and downregulated Lachnospiraceae and Phascolarctobacterium after adrenocorticotropic hormone (ACTH) treatment (Fairlie et al., 2020). The gene discussed is POMC; the disease is infantile spasms.