Secondly, a high proportion of patients with abnormal antiphospholipid antibody spectrum was observed: 60% of the COVID-19 patients who developed MOG-ON symptoms within 6 weeks had abnormal antiphospholipid antibody spectrum, characterized by increased β2 glycoprotein antibody, decreased protein S, decreased antithrombin III percentage, and increased LA1/LA2 levels. The gene discussed is SERPINC1; the disease is COVID-19.