Additionally, cases of Aquaporin-4 Antibody (AQP4-Ab) positive Neuromyelitis Optica Spectrum Disorder (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody (MOG-Ab)-associated Disease (MOGAD) have also emerged post-COVID-19 vaccination or infection (6–13), suggesting that SARS-CoV-2 infection may precipitate the onset of ON or even the production of MOG-Ab and AQP4-Ab (14). This evidence concerns the gene AQP4 and infection.