For cognitive deterioration over the disease course, six SNPs (rs115185635, rs11724635, rs591323, rs13294100, rs2251776, and rs12456492) and ApoE ε4 were associated with faster cognitive decline at p < 0.05, and only rs591323 (residing in FGF20, p = 0.0007; Table 2) passed correction for multiple testing (p < 0.0011). The gene discussed is APOE; the disease is Mental deterioration.