In this relation, Canavese and colleagues investigated the effect of statins on the Plasmodium berghei Anka mouse model of cerebral malaria. The administration of Lovastatin had an upregulating effect on TNF-α, HO-1 and NRF2, as well as a downregulatory effect on INF-γ [25]. This evidence concerns the gene HMOX1 and cerebral malaria.