In this relation, Canavese and colleagues investigated the effect of statins on the Plasmodium berghei Anka mouse model of cerebral malaria. The administration of Lovastatin had an upregulating effect on TNF-α, HO-1 and NRF2, as well as a downregulatory effect on INF-γ [25]. The gene discussed is TNF; the disease is cerebral malaria.