Identification of an alternative ligand‐binding pocket in proliferator‐activated receptor gamma (PPARγ), and screening out NJT‐2, a natural compound derived from Bupleurum chinense DC, binds in this pocket, induces the coactivator recruitment, guides the PPARγ binding to the promotors of beige adipocyte‐related genes, thus enhances white adipose tissue browning and improves the metabolic disorders without the similar adverse effects observed with thiazolidinediones. The gene discussed is PPARG; the disease is Other metabolic disease.