The results indicated that NAMPT-(ITGA5-ITGB1), TNF-TNFRSF1B, and TNF-TNFRSF1A were signaling pathways upregulated in AD, while LGALS9-CD45 and ANXA1-FPR1 were signaling pathways downregulated in AD. The gene discussed is TNFRSF1A; the disease is Alzheimer disease.