Recent studies have shown that the APP intracellular domain (AICD) of the amyloid-β precursor gene is a potential contributor to the development and progression of AD (Konietzko, 2012), and that activation of CUX1 transcriptional activity by the AICD may be implicated in its contribution to AD (Yang et al., 2012). The gene discussed is CUX1; the disease is Alzheimer disease.