In a study of myocardial fibrosis, Li et al found that FTO down-regulated Dickkopf WNT signaling pathway inhibitor 2 (DKK2) m6A methylation, reduced the association of miR-636 to DKK2, promoted the DKK2 expression, and inhibited cardiac fibroblasts and myocardial apoptosis. The gene discussed is DKK2; the disease is Myocardial fibrosis.