YTHDF2 and familial dilated cardiomyopathy: Shao et al found that ALKBH5 post-transcriptionally activated forkhead box O3 (FOXO3) by demethylation of m6A via YTHDF2, enhanced cerebellar degeneration-related protein 1 antisense (CDR1as) expression, and then activated Hippo signaling pathway conducing to cardiomyocyte apoptosis in DCM mice.131