METTL3 and ischemic cardiomyopathy: Among them, m6A exhibited conflicting roles, METTL3 promotes cardiomyocyte apoptosis while METTL14 inhibits cardiomyocyte apoptosis to affect the progression of ischemic cardiomyopathy,103,120 which would be due to different models of disease or differences in m6A mRNA status and function or different physiological and pathological environments.