Furthermore, METTL14 down-regulates lncRNA TINCR by elevating its m6A level in a YTHDF2-dependent manner and destabilizes NLRP3 mRNA through the TINCR-NLRP3 pathway, further inhibiting cardiomyocyte pyroptosis and DCM progression.108. The gene discussed is NLRP3; the disease is familial dilated cardiomyopathy.