The down-regulation of METTL14 leads to reduced fibroblast growth factor receptor 4 (FGFR4) mRNA decay through m6A RNA hypomethylation, thus initiating the β-catenin/TCF4-SLC7A11/FPN1 pathway to develop anti-HER2 resistance in breast cancer by attenuating ferroptosis.113. This evidence concerns the gene ERBB2 and breast cancer.