Furthermore, METTL14 down-regulates lncRNA TINCR by elevating its m6A level in a YTHDF2-dependent manner and destabilizes NLRP3 mRNA through the TINCR-NLRP3 pathway, further inhibiting cardiomyocyte pyroptosis and DCM progression.108. This evidence concerns the gene METTL14 and familial dilated cardiomyopathy.