Shao et al found that ALKBH5 post-transcriptionally activated forkhead box O3 (FOXO3) by demethylation of m6A via YTHDF2, enhanced cerebellar degeneration-related protein 1 antisense (CDR1as) expression, and then activated Hippo signaling pathway conducing to cardiomyocyte apoptosis in DCM mice.131. The gene discussed is ALKBH5; the disease is familial dilated cardiomyopathy.