A recent examination revealed that METTL3 is up-regulated to reduce the protein levels of solute carrier family 7 member 11 (SLC7A11) and ferroptosis-suppressor-protein 1 (FSP1) by promoting their mRNA degradation, leading to facilitating ferroptosis of human aortic smooth muscle cells (HASMCs) and aortic dissection progression. This evidence concerns the gene AIFM2 and Aortic dissection.