For example, EZH2-mediated H3K27me3 and DNMT1-mediated DNA methylation in ovarian cancer reduce the levels of the chemokines CXCL9 and CXCL10 secreted by helper T cells (Th1), increasing CD8+ T cell infiltration, and inhibiting tumor growth.54 The gene discussed is DNMT1; the disease is neoplasm.