NAMPT and melanoma: NAMPT, the key enzyme involved in the salvage pathway of NAD+ synthesis, has been found up-regulated in various types of cancer, including COAD,123 ovarian cancer,124 breast cancer,125 and melanoma,126 and is associated with poor prognosis.127, 128, 129 Inhibiting NAMPT has been shown to reduce NAD+ levels, leading to cancer cell death and impeding tumor growth.127