Glutamine is a nonessential amino acid (NEAA) that enters the cell via the amino acid transporters, such as ASCT2/SLC1A5, and is then catalyzed to glutamate by glutaminase in the mitochondria, and mitochondrial glutamate is subsequently converted into α‐ketoglutarate (α‐KG), which can help rapidly proliferating cancer cells meet the increasing demand for ATP and biosynthetic precursors and reducing agents [8, 9]. The gene discussed is SLC1A5; the disease is cancer.