AKT1 and hepatocellular carcinoma: The solid-state cultured broth of T. camphoratus also managed to exert synergistic antiproliferative effects in C3A and PLC/PRF/5 hepatoma cells when administered in combination with cisplatin and mitomycin via the inhibition of the multidrug resistance (MDR) gene expression and the cyclooxygenase-2 (COX-2)-dependent inhibition of phospho-protein kinase B (p-Akt), which in turn resulted hepatoma cells to undergo apoptosis [173].