RELA and central nervous system cancer: CBD also facilitates the DNA binding of the glioma cell NF-κB subunit RELA, while preventing the phosphorylation of RELA on Serine-311 through the downregulation of protein kinase C ζ (PKCζ), with the sustained DNA binding of non-phosphorylated Serine-311 RELA mediating GSC cytotoxicity.