CBD treatment results in the downregulation of key proteins associated with tumor invasion and angiogenesis, such as matrix metalloproteinase-9 (MMP-9), tissue inhibitors of metalloproteinase 1 and 4 (TIMP1/4), urokinase plasminogen activator (uPA), SerpinE1-plasminogen activator inhibitor type-1 (Ser-PAI-1), vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1), C-X-C motif chemokine 16 (CXCL-16), platelet-derived growth factor-AA (PDGF-AA), monocyte chemotactic protein-1 (MCP-1), angiogenin, and hypoxia-inducible factor-1α (HIF-1α) [32]. This evidence concerns the gene SERPINE1 and neoplasm.