Given the importance of METTL3 (N6-adenosine-methyltransferase) and ALKBH5 (RNA demethylase) in m6A modification [45] and their link to Wilms tumor susceptibility [19, 46], we conducted MeRIP following overexpression of these enzymes (Fig. 6F). This evidence concerns the gene METTL3 and Wilms tumor.