After 500 iterations it was determined that the six variables most closely associated with all-cause mortality (in order of z-value, excluding the insulin resistance replacement index) were age, CVD, Scr, SBP, BUN and hypertension, and the six variables most closely associated with cardiovascular mortality were age, HbA1C, FPG, Scr, ALT and SBP. The gene discussed is INS; the disease is Hypertension.