RRAS2 and breast cancer: To determine whether the C allele favors the overabundance of RRAS2 mRNA in BC tumor samples, a luciferase expression construct was generated in which the 3’UTR region of human RRAS2 mRNA with either a G or C residue at the SNP position was fused downstream of the cDNA encoding the reporter gene luciferase (Fig. 7f).