As for the TLRs; TLR1, TLR7 and TLR8 that were previously significantly upregulated in IP of serum and tissue lysates of CRC were found to be significantly decreased by 19 times for TLR1 as well as TLR8 and 57 times for TLR7 in cells transfected with miRNA mimics; miRNA-122, miRNA-29b and miRNA-15b with a highly significant difference compared to the mock group (p < 0.01) in LS174T and HT-29 cell lines. Here, TLR1 is linked to colorectal carcinoma.