TLR8 and benign neoplasm: We found the protein expression of TLR1, TLR7 and TLR8 to be aberrantly upregulated in CRC cases compared to their protein expression in benign neoplasms cases and healthy control samples in agreement to the studies of [33] who reported the up regulation of TLR1, TLR7 and TLR8 in CRC patients in comparison to control individuals [14].