Applying bioinformatics analysis, three TLRs; TLR1, TLR7 and TLR8 and seven miRNAs (Hsa-miR122,hsa-miR29b,hsa-miR 15b, hsa-miR202, hsa-miR 98, hsa-miR 21 and hsa-miR let 7i) were selected from public data bases, based on high ranking score of their differential expression in CRC compared to controls. This evidence concerns the gene TLR1 and colorectal carcinoma.