The association with HCC was replicated in UKB dataset for ALT (OR = 1.10, 95% CI: 1.02–1.18), AST (OR = 1.30, 95% CI: 1.09–1.55), MASLD (OR = 15.66, 95% CI: 6.81–36.02), percent liver fat (OR = 25.50, 95% CI: 10.79–60.28), and liver iron content (OR = 6.17, 95% CI: 2.08–18.31). The gene discussed is GPT; the disease is hepatocellular carcinoma.