The ROH islands contained several interleukin genes (IL4, IL5, IL13), which, together with their associated receptors, have been implicated in inflammatory processes such as recurrent airway obstruction and summer-pasture associated obstructive pulmonary disease (IL4, IL13 [62–64]) or insect bite hypersensitivity (IL5 [65–67]). Here, IL5 is linked to Airway obstruction.