Although previous studies have shown that people with immunosuppression caused by HIV, as indicated by a low CD4 count, have weaker responses to COVID-19 vaccines as a result of persisting immune dysfunction, exhaustion, and immune senescence [44], the current study adds to the growing body of evidence that COVID-19 vaccines induce significant antibody responses in PLWH under a regular regimen of antiretroviral therapy (ART) [25, 26, 45, 46]. Here, CD4 is linked to immune system disorder.