For example, E2-BSA conjugate, as did the unconjugated E2, could act via a membrane version of the estrogen receptor α on pituitary tumor cells and breast cancer cells and provoke Ca2+ influx via L-type channels, leading to prolactin secretion, suggesting the existence of the non-genomic responses mediated by membrane estrogen receptor α37. The gene discussed is ESR1; the disease is breast cancer.