MAPT and Alzheimer disease: Reconstructed tomographic volumes revealed the native, in-tissue, 3D molecular architecture of AD pathology in postmortem brain (Figs. 1h,i and 2, also Supplementary Videos 1–3 from an amyloid plaque, Supplementary Videos 4–6 from tau tangles and threads and Supplementary Videos 7–9 from non-demented control).