TTR and infection: These adenoviruses differed in their promoters driving viral gene expression and the outcome of infection, a cytomegalovirus promoter (Ad–CMV–GOL) leading to acute resolved infection with transient liver damage compared to a hepatocyte-specific transthyretin promoter (Ad–TTR–GOL) leading to persistent infection with continuous low-level liver damage (Fig. 1a and Extended Data Fig. 1a–f).