Approximately 85% of ES cases exhibit chromosomal translocations that lead to the generation of genomic rearrangements involving the breakpoint region 1 (EWSR1) gene and members of the E26 transformation-specific (ETS) family of transcription factors, with the fusion of EWSR1 to FLI1 being the most frequently observed, resulting in the formation of the EWS/FLI fusion protein [3]. The gene discussed is EWSR1; the disease is Ewing sarcoma.