In the current investigation, we observed that the expression of SETD8 was elevated in ES, corroborating prior findings that SETD8 is overexpressed across a spectrum of malignancies, including neuroblastoma [13], pancreatic carcinoma [12], cervical cancer [24], multiple myeloma [25], and colorectal cancer [14]. This evidence concerns the gene KMT5A and cervical carcinoma.