Acid-sensing ion channel 1a (ASIC1a), phospholipase D1 (PLD1), Aquaporin 1, and neuron navigator 2 (NAV2) all show a promotive effect on RA by activating Wnt/β-catenin signaling.391–394 ASIC1a, PLD1, Aquaporin 1, and NAV2 promote cell proliferation, migration, invasion, and inflammation of RA FLS through activating the Wnt/β-catenin pathway.391–394 Moreover, noncoding RNAs are involved in RA by regulating Wnt signaling. The gene discussed is PLD1; the disease is rheumatoid arthritis.