FOXB2 and cancer: FOXB2, an uncharacterized forkhead-box family transcription factor, was recently identified as a potent activator of Wnt signaling in normal and cancer cells by Moparthi et al.103 They found that FOXB2 induced multiple Wnt ligands, including Wnt7b, to increase TCF/LEF-dependent transcription without activating Wnt co-receptor LRP6 or β-catenin.