In this work, we perform scRNAseq on both the immune and non-immune compartments of the TME, revealing a CAF-secreted myeloid cell regulating mediator, called TNF-stimulated gene 6 (TSG-6) enriched in pancreatic tumors compared to melanoma tumors, in both murine models and patient samples. The gene discussed is TNFAIP6; the disease is melanoma.