BRAF and neoplasm: A similar trend was observed in the PBTA RNAseq cohort (Fig S5a), in which tumors with BRAF fusions (median TIS = 6.98; p = 3 × 10−4), BRAF V600E (median TIS = 7.34; p = 4.2 × 10−6), and non-canonical MAPK pathway alterations (median TIS = 7.18; p = 0.0024) had significantly higher inflammation than non-tumor brain (median TIS = 5.75).