Interestingly tumors from 3 Li-Fraumeni syndrome (LFS) patients (median TIS = 9.24; p = 0.009 vs. normal brain, Wilcoxon test), had higher inflammation than most somatic TP53-mutant HGG (median TIS = 8.3, p = 0.05 vs. normal brain, p = 0.26 vs LFS patients). The gene discussed is TP53; the disease is Li-Fraumeni syndrome.