We have recently reported that an integrated Five-Biomarker Panel (iFBPanel) (EFNA1, MMP13, CEA, Cyfra21-1 and squmaous cell carcinoma antigen) might be used as a blood biomarker-based tool to identify early-stage esophageal squamous cell carcinoma (ESCC)24. The gene discussed is EFNA1; the disease is esophageal squamous cell carcinoma.