EFNA1 and esophageal squamous cell carcinoma: Moreover, our previous studies also showed that the expression of serum EFNA1 in ESCC was significantly higher than that of normal controls indicating EFNA1 as a novel serum marker for the detection of cancers. Here, we showed the potential utility of EFNA1 in the early diagnosis of GC which furtherly confirms the crucial role of soluble EFNA1 in the progression of tumors.