In UPN6 and 7, TET2-mutated clones were identified both at the initial diagnosis and AML transformation, while TP53, IDH2, and NRAS mutations in UPN6 and TP53, SRSF2, and CBL mutations in UPN7, which were additionally identified in transformed AML, were not detected at the initial diagnosis. The gene discussed is SRSF2; the disease is acute myeloid leukemia.