Using complementary studies of fresh asthmatic and cultured HAECs, we identify an external 15LO1, PLox and mitochondrial-targeted ferroptotic signal, an optineurin-driven, PTEN-induced kinase (PINK)−1/Parkin mediated mitophagic response and their combined functional relevance to ciliary cell phenotypes and worsened asthma outcomes. This evidence concerns the gene OPTN and asthma.