CHD8 and Impaired glucose tolerance: These include rs6769383, whose nearest gene EDEM1 is involved in carbohydrate metabolism48, rs2861761, whose nearest gene TENM2 is enriched in white adipocytes49, rs11156978 whose nearest gene CHD8 is associated with impaired glucose tolerance in mouse knockouts50, and rs7962636, whose nearest gene MED13L is a transcriptional regulator of white adipocyte differentiation51.