This HRS umbrella definition therefore includes, apart from ARVC, a broad spectrum of systemic (e.g. sarcoidosis, amyloidosis), inflammatory/infectious (e.g. myocarditis, Chagas disease), and (left-dominant) genetic (e.g. Lamin A/C [LMNA], Filamin C [FLNC]) heart diseases. This evidence concerns the gene FLNC and arrhythmogenic right ventricular cardiomyopathy.