ACOD1 and arthritic joint disease: Assessing a potential role of Irg1 in another model of arthritis, the K/BxN serum transfer arthritis model,21 again showed no clear differences between Irg1+/+ and Irg1−/− mice in both the clinical course of arthritis and osteoclast-related parameters in histological sections (figure 3J, K and online supplemental figure S3e, f).