Using the 2,342 m5C sites derived from HeLa cells (Fig S6E) or the 3,965 mRNA sites from our union set (Fig 4B) yielded seven RBPs enriched in both comparisons, the five seen before plus FTO (Fat mass and obesity associated) and AKAP1 (A-kinase anchoring protein 1). The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.