NEK1 and amyotrophic lateral sclerosis: We have found three individuals with a NEK1 mutation through gene panel sequencing in a longitudinal cohort of Scottish ALS patients [22], two with novel heterozygous 5′ splice site mutations, (i) c.214 + 1G > A and (ii) c.1911 + 1 > TATA, and one with a previously characterised heterozygous missense mutation, (iii) c.782G > A, p.Arg261His [4].