TRPM8 and asthma: Wang et al. (2017) suggested that during cold stress, TRPM8 could inhibit the dissociation and nuclear translocation of NF-κB, and negatively regulate TNF-α expression in the hypothalamus of mice. In addition, activation of TRPM8 by low temperatures can inhibit the P38 pathway, thereby playing a therapeutic role in asthma (Zhang et al., 2016).