MAPT and Alzheimer disease: However, recent clinical evidence supports the existence of distinct astrocyte biomarker signatures triggered by brain Aβ and tau pathology.30 In a murine model of AD, Aβ and tau induced overlapping reactive astrocyte profiles associated with both deleterious and neuroprotective signals.48 Further characterizing the context-specific astrocyte biomarker signature of AD is a priority to enhance our understanding of astrocytes' role in AD pathophysiology.