SH3PXD2B and lung cancer: Next, we confirmed the involvement of multiple proteins in the Tks4 interactome by immunoprecipitating endogenous Tks4 protein from different NSCLC lung cancer cell lysates (A549: human lung adenocarcinoma, HOP-92: human lung non–small cell carcinoma, NCI-H460: human lung large cell carcinoma) and performing WBs (Figure 6B).