CDH2 and lung cancer: Furthermore, our findings revealed an epithelial/mesenchymal hybrid phenotype in Tks4-KO lung cancer cells characterized by increased gene expression levels of mesenchymal markers, for example, fibronectin, N-cadherin, and Snail2 transcription factor, while the expression of the epithelial marker E-cadherin was decreased in the Tks4-KO clones (Figure 4A).