SH3PXD2B and cancer: To gain a deeper insight into the diverse outcomes of Tks4-dependent signaling pathways, we surveyed the Tks4-binding partners described in the literature and performed Tks4 immunoprecipitation followed by mass spectrometry (Tks4-IP-MS) in five cancer cell lines (including A549 lung adenocarcinoma cells) to identify additional possible Tks4-associated EMT-related proteins.