TKT and Cognitive impairment: To date, the TK pathway and IDO activation have only been reported as associated with global cognitive deficits in a sample of predominately men with HIV.20,32 Here, we examine the association between TK pathway metabolites and domain-specific cognitive dysfunction in VS-WWH and demographically similar women without HIV (WWoH) coenrolled in the Women's Interagency HIV Study (WIHS) and “IDOze” substudy of sleep and the TK pathway in WWH and WWoH.22,23