Carriers of hematopoiesis of indeterminate potential (CHIP) were shown to have a 1.9-fold increased risk of heart disease compared with non-carriers, and somatic mutations in DNA methyltransferase DNMT3A, DNA demethylase TET2, additional sex combs-like 1 ASXL1, and Janus kinase 2 JAK2 have been associated with ischemic heart disease [34]. The gene discussed is JAK2; the disease is heart disorder.