In addition, the serum level of lncRNA MEG3 was significantly low in patients with sepsis, and they confirmed this relation by invitro culture of human macrophages which showed highly expressed MEG3 can reduce apoptosis of the macrophages and secretion of inflammatory factors via suppression of NF-KB signaling pathway (Pan and He 2020). This evidence concerns the gene NFKB1 and Sepsis.