CALCR and carcinoma: As the IHC figures shown, CALCR was markedly upregulated in RCC tissues, especially in advanced RCC tissues, compared with normal para-carcinoma tissues (para-carcinoma vs. stage I, P < 0.001; para-carcinoma vs. stage III, P = 0.004; para-carcinoma vs. stage IV, P < 0.001) (Figure 1A, 1B, Table 1).