Besides, correlation analysis between CALCR expression and tumor characteristics in RCC patients suggested that the overexpression of CALCR was positively associated with tumor stage (P = 0.003), T infiltration (P = 0.039), metastasis (P = 0.012) and lymphatic metastasis (P = 0.031) (Table 2), which was confirmed by Spearman correlation analysis (Table 3). The gene discussed is CALCR; the disease is renal cell carcinoma.