Cao etal. (2008) found that overexpression of ΔNp63α in RCC couldup-regulate the protein and mRNA levels of the SHH signaling pathway. Dietarydiallyl trisulfide inhibited gastric cancer stemness by ΔNp63/SHH pathway (Ge et al., 2023). Another studysuggests that the IL-6/ΔNp63α/Notch axis plays a vital role in the long-term tobaccosmoke exposure-induced acquisition of lung CSC-like properties (Xie et al., 2019). Here, SHH is linked to renal cell carcinoma.