POU5F1 and nonpapillary renal cell carcinoma: Ma et al. (2023) indicated that inhibition ofthe expression of a significant marker of CSCs, i.e., CD44, may be a new therapy tosuppress ccRCC progression. Oct4, a stem cell transcription factor, and itsoverexpression was closely related to the progression of several malignancies,including ovarian cancer (Xie et al., 2022),prostate cancer (Yasumizu et al., 2020), andrenal cancer (Zhang et al., 2023).Overexpression of SOX2 is associated with cancer development, poor prognosis, andchemoresistance in several types of cancers (Mirzaeiet al., 2022).