ORAI1 and chronic pancreatitis: Recently another Orai1/CRAC channel inhibitor, CM5480, was also successfully used to inhibit the progression of recurrent AP to chronic pancreatitis (CP) by protecting against Ca2+ overload in pancreatic acinar and duct cells.53,54 However, it is also paramount to consider the risks and the benefits of prolonged treatments with Orai1/CRAC channel blockers for patients with AP or CP.