ORAI1 and immune system disorder: In humans, CRAC channelopathies with loss-of-function mutations in Orai1 predispose to severe immunodeficiencies, autoimmunity, muscular hypotonia, and other abnormalities.32 Waldron et al. have demonstrated the profound effect of CM4620 on the immune cells in the pancreas.42 Therefore, the long-term inhibition of Orai1/CRAC channels with Auxora should be considered with caution.