- 13 Other known causes of AP are either hereditary13 or due to side effects of some drugs, such as cancer drugs based on l-asparaginase (ASNase), an essential treatment received by patients suffering from acute lymphoblastic leukemia (ALL), the most common type of cancer affecting children.14 The development of ASNase-induced AP (AAP) in up to 10% of cases becomes the most common reason for ending this life-saving treatment.15 The gene discussed is ASPG; the disease is alkaline phosphatase measurement.