The WD has been associated with an increased incidence of T2D, tubular injury, and chronic kidney disease in humans.30,31 We hypothesized that reduced expression of SGLT2 in Lrp2 KO mice would confer higher glucose tolerance, similar to that seen in SGLT2 (Slc5a2) KO animals and in wild-type mice treated with SGLT2is.32,33. Here, SLC5A2 is linked to chronic kidney disease.