GCGR and hepatocellular carcinoma: Although similar trafficking profiles have not been determined for the GCGR in primary cells, studies in HEK293T and human hepatoma (Huh7) cells have shown that this receptor is associated with a slow internalization and fast recycling profile in response to glucagon stimulation, with a report demonstrating intracellular retention of GCGR being triggered by RAMP2 coexpression (81).