NOTCH4 and neoplasm: Notably, the translatomic signature within the tumor ECs after a few days of treatment with 6-3-A6 revealed increased activity of VEGF signaling, suggesting that Notch4 signaling may attenuate angiogenesis in tumors and that the increase in vessel area observed after extended 6-3-A6/E7011 treatment may in fact be due to Notch4 inhibition.