Indeed, direct microneurographic recordings from human C-fibres have shown that patients with a variety of painful conditions including painful small fibre neuropathy, painful diabetic neuropathy, and fibromyalgia display marked ongoing activity in C-fibres as well as sensitization.44-50 The fact that the mutations here relieve voltage block of the PIEZO2 channels strongly suggests that physiological or pathological sensitization of nociceptors partially requires PIEZO2 channels. This evidence concerns the gene PIEZO2 and diabetic neuropathy.