PIEZO2 and peripheral neuropathy: Indeed, direct microneurographic recordings from human C-fibres have shown that patients with a variety of painful conditions including painful small fibre neuropathy, painful diabetic neuropathy, and fibromyalgia display marked ongoing activity in C-fibres as well as sensitization.44-50 The fact that the mutations here relieve voltage block of the PIEZO2 channels strongly suggests that physiological or pathological sensitization of nociceptors partially requires PIEZO2 channels.