In a recent study, a mouse model was generated carrying a Nav1.7 (I228M) gain-of-function variant which has been associated with painful small fibre neuropathy in patients.35 The Nav1.7 (I228M) mice show sensory neuron hyperexcitability to a remarkably similar degree as the mouse mutants we described here; however, in contrast, these mice do not exhibit severe mechanical hypersensitivity as we have shown here for Piezo2R2756H/R2756H and Piezo2R2756K/R2756K mice (Fig. 8). This evidence concerns the gene SCN9A and peripheral neuropathy.