Protosappanin A (PrA), an active constituent extracted from traditional Chinese hematoxylin, has been associated with multiple pharmacological properties, including antioxidative, anti‐inflammatory, and anti‐apoptotic activities.[10] Our previous research demonstrated that PrA could exert an immunosuppressive effect on cardiac transplantation and autoimmune myocarditis via NF‐κB and Akt/mTOR.[11] Despite recent advances, the role of PrA in DIC and its relationship with ferroptosis remain unclear. The gene discussed is S100A6; the disease is autoimmune myocarditis.