A potential pathogenic role of PLG/T481M is supported by the fact that this variants has been reported as a somatic variants of PLG in primary tissue from various cancers, including central nervous system glioma, large intestinal adenocarcinoma, endometrial carcinoma, esophageal carcinoma, and stomach carcinoma (COSV51981707) (146). Here, PLG is linked to colorectal adenocarcinoma.