The PLG/K19E variant and other relatively abundant variants of concern found in PDI or PDII, viz., R234H (Tables 2, 4) and PLG/G693R (Tables 2, 3, 6, 8), have been reported in patients with atypical hemolytic uremic syndrome (AHUS) (175). The gene discussed is PLG; the disease is atypical hemolytic-uremic syndrome.