Mice with a total deficiency of PLG (mouse PLG−/−) have severe lifelong challenges, including deficiencies in vascular wound healing (204) and vascular remodeling after arterial injury (205), as well as venous and arterial thrombosis (134), despite the fact that PLG is not the only fibrin degrading enzyme in the vasculature (89, 90). The gene discussed is PLG; the disease is Venous thrombosis.