MAPT and Alzheimer disease: Neuropathologically, AD is identified by the presence of extracellular amyloid plaques primarily composed of amyloid beta (Aβ) peptides and intracellular neurofibrillary tangles (NFTs) consisting of hyperphosphorylated tau (p-tau) in the hippocampus and cortex (Glenner and Wong, 1984; Brion et al., 1991; Buée et al., 2000; Congdon and Sigurdsson, 2018; Panza et al., 2019).